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International Women’s Day #IWD2021

Written by Centre Manager, Dr Susan Northfield

Today is International Women’s Day #IWD2021, and this year the theme is #ChooseToChallenge. “A challenged world is an alert world. Individually, we’re all responsible for our own thoughts and actions – all day, every day. We can all choose to challenge and call out gender bias and inequality. We can all choose to seek out and celebrate women’s achievements. Collectively, we can all help create an inclusive world.”

Our Centre has embraced the challenge to ensure diversity, gender equality and inclusion from day one; specifically identifying it as one of our key policies to make certain the Centre promotes a positive and fair workplace culture for all participants at all times. This policy guides our processes and decision-making as we develop opportunities for the students and ECRs in our care.

In the spirit of #ChooseToChallenge, we want to shine a light on what this approach looks like for us. For example, Centre participants are expected to:

  • Ensure invited speakers, panel compositions, other representatives required for Centre training and conferences etc., are of diverse backgrounds, including gender;
  • Ensure we advertise in such a way as to attract and subsequently enroll representative numbers of male/female students and postdoctoral researchers in the Centre;
  • Provide diversity in mentor-mentee pairs;
  • Provide key contacts at each University for anyone experiencing discrimination;
  • Adhere to the ten principles of the Athena SWAN Charter

Today we celebrate the women of our Centre – students, postdocs, chief investigators, executive members, and industry board members. The photo accompanying this post shows a handful of the women at our University of Melbourne #ARCCPTT node, from the Department of Biochemistry & Pharmacology. I want to thank them and all members of the Centre for contributing to providing a diverse, inclusive and supportive environment as we commit to #ChooseToChallenge and call out inequality. #IWD2021

Funding success for CPTT CI’s

The Centre congratulates two of our CI’s – Prof Spencer Williams & Prof Alastair Stewart – on their successful Accelerator Grant from Therapeutic Innovation Australia!

Their grant “Development of casein kinase 1 delta inhibitors for inflammation, fibrosis and fibrotic cancers” is in collaboration with Tianli Biotech Pty Ltd.

Outcomes for the recent round were announced at the end of February. For the full list of winners, visit the Therapeutic Innovation Australia website: https://www.therapeuticinnovation.com.au/p-accelerator2020-21-outcomes

New study: What makes you prone to tendon & ligament injuries?

Why are some people more prone to tendon and ligament injury than others?

We are delighted to promote a recent study by one of our CI’s, Prof Minghao Zheng, Director of the Centre for Translational Orthopaedic Research at The University of Western Australia and Chief Scientific Officer of our industry partner Orthocell.
This study has been published in top medical journal, Science Translational Medicine on February 25th. See a copy of the article here:  http://bit.ly/3suluH5

Prof. Zheng noted that the study offers new insights in the medical world by highlighting genetic factors responsible for sports injuries, including the commonly reported ACL rupture.

You can view the University of Western Australia’s press release, including a short video, via this link: https://www.uwa.edu.au/news/Article/2021/February/Some-more-prone-to-tendon-and-ligament-injuries

“Engineering drug discovery: Process and Passion” – A Public Lecture from CPTT Director

On March 4th our Centre Director, Professor Alastair Stewart (Department of Pharmacology & Therapeutics, The University of Melbourne) was invited to give a lecture in the Graeme Clark Institute’s ‘Biomedical Engineering Advances’ lecture series at the Doherty Institute for Infection and Immunity in Melbourne.

Prof Stewart discussed the long and precarious path to success for development of therapeutics for lung disease. His presentation “Engineering drug discovery: Process and Passion” was well received by those in the audience and generated vibrant discussion afterward.

We are delighted to say that the lectures in this series are being recorded, and are available to view on YouTube. If you would like to watch Prof Stewart’s presentation, please follow this link.

Award for CI Megan Munsie

CI Munsie from our Melbourne University node has been awarded the 2018 Stephen Crook Memorial Prize for best authored book in Australian Sociology by The Australian Sociological Association (TASA) for her book titled Stem Cell Tourism and the Political Economy of Hope.

Authors included CI Munsie and collaborator Dr Claire Tanner from the Stem Cell Centre and Jane Brophy a Monash PhD student CI Munsie co-supervised. The book is the culmination of an eight year collaboration with Prof Alan Petersen from Monash Arts Faculty which has been supported by an ARC Discovery grant and some additional seed funding from the Commonwealth Dept of Industry. 

The book was published in 2016 by Palgrave Macmillan as part of a Health, Technology and Society series and provides a unique and innovative perspective on the controversial phenomenon of ‘stem cell tourism’ where a growing number of patients are embarking on stem cell treatments that are clinically unproven and yet available in clinics and hospitals around the world. We describe this complex and rapidly changing phenomenon, including an analysis of the experiences of those who have undertaken or have contemplated undertaking a stem cell treatment, as well as examination of the views of those who undertake research or advise on or provide stem cell treatments. Developing the concept of ‘the political economy of hope’, and referencing case studies of the stem cell treatment market in China, Germany, and Australia, we call for a reframing of ‘stem cell tourism’ to understand why patients and families pursue these treatments and whether response by government authorities and others are appropriate and proportionate to the alleged risks.

Congratulations to the team for having their multidisciplinary work recognised.

New Publication – iScience

Researchers from the Melbourne University node of the ARC CPTT have published a  new paper in interdisciplinary (Cell Press) open access journal iScience titled “A Non-canonical Pathway with Potential for Safer Modulation of Transforming Growth Factor-β1 in Steroid-Resistant Airway Diseases“.

Highlights from the paper:
•TGF-β1 extensively impairs GC activity
•Phospho-cofilin1 is a key link of TGF-β1 signalling cascade subserving GC insensitivity
•Phospho-cofilin1-activated phospholipase D (PLD) reduces GC activity
•SMRT induction downstream of PLD mediates TGF-β1 impairment of GC activity

Summary
Impaired therapeutic responses to anti-inflammatory glucocorticoids (GC) in chronic respiratory diseases are partly attributable to interleukins and transforming growth factor-β1 (TGF-β1). However, previous efforts to prevent induction of GC insensitivity by targeting established canonical and non-canonical TGF-β1 pathways have been unsuccessful. Here we elucidate a TGF-β1 signalling pathway modulating GC activity that involves in LIM domain kinase 2-mediated phosphorylation of cofilin1. Severe, steroid-resistant asthmatic airway epithelium showed increased levels of immunoreactive phospho-cofilin1. Phospho-cofilin1 was implicated in the activation of phospholipase D (PLD) to generate the effector(s) (lyso)phosphatidic acid, that mimic the TGF-β1-induced GC insensitivity. TGF-β1 induction of the nuclear hormone receptor corepressor, SMRT (NCOR2), was dependent on cofilin1 and PLD activity. Depletion of SMRT prevented GC insensititvity. This pathway for GC insensitivity offers several promising drug targets that potentially enable a safer approach to modulation of TGF-β1 in chronic inflammatory diseases than is afforded by global TGF-β1 inhibition.

PhD Scholarship opportunities – UWA node

One ARC Industrial Transformation Training Centre PhD Scholarship is available for a student to carry out the following project at our UWA node:

Mechanobiology of 3D bioprinted scaffolds

 

Other scholarships available at UWA that may be affiliated with the Centre are the BioZone PhD Scholarships.

The BioZone at UWA brings together researchers with a shared vision and purpose from across the University. We seek innovative solutions that address the increasing complexity of local and global challenges and ‘wicked problems’. These problems require transformative change in the way we learn, think and interact and the BioZone PhD program will train the next generation of researchers to work across disciplines and create imaginative and revolutionary outcomes.

 

 

ARC PD in real-time live cell assay technologies

Our UWA node is now currently recruiting for an ARC Postdoctoral Fellow who will participate in the research program of the ARC Centre for Personalised Therapeutics Technologies within the Faculty of Health and Medical Sciences at the Harry Perkins Institute of Medical Research.

The Postdoctoral Fellow will manage the day-to-day running of the Centre for Personalised Therapeutics Technologies project entitled ‘Development and utilisation of real-time live cell assay technologies and complementary diagnostics to improve profiling of therapeutics’.

For further information download the UWA CPTT ICPD Position Description

Applications close 18th October 2018.

Accelerating Australia National Conference – Nov 27th in Adelaide

The Accelerating Australia National Conference is being held alongside the ASCEPT Scientific Meeting in Adelaide.

Register for this one day Accelerating Australia event with keynote from Daria Mochly-Rosen, Founder and Co-director of Stanford SPARK.

See the Accelerating Australia Conference Flyer for further information.

Note: if you are going to ASCEPT you  can attend this one day event for free as part of your ASCEPT registration.